Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice

Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice

Atherosclerosis and resulting cardiovascular disease are the leading causes of death in the US. Hyperhomocysteinemia (HHcy), or the accumulation of the intermediate amino acid homocysteine, is an independent risk factor for atherosclerosis, but the intricate biological processes mediating this effec...

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Bibliographic Details
Main Authors: Stephen G. Andrews, Anthony M. Koehle, Devendra Paudel, Thomas Neuberger, A. Catharine Ross, Vishal Singh, Teodoro Bottiglieri, Rita Castro
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Nutrients
Subjects:
atheroma
vascular disease
hypomethylating stress
high-field MRI
Online Access:https://www.mdpi.com/2072-6643/16/3/330

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https://www.mdpi.com/2072-6643/16/3/330

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