Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome

Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome

High-risk neuroblastoma (NB) is a rare childhood cancer whose aggressiveness is due to a variety of chromosomal genetic aberrations, including those conferring immune evasion. Indeed, NB cells adopt several molecular strategies to evade recognition by the immune system, including the downregulation...

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Bibliographic Details
Main Authors: Elisa Brandetti, Chiara Focaccetti, Annalisa Pezzolo, Marzia Ognibene, Valentina Folgiero, Nicola Cotugno, Monica Benvenuto, Paolo Palma, Vittorio Manzari, Paolo Rossi, Doriana Fruci, Roberto Bei, Loredana Cifaldi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
neuroblastoma
NK cell-mediated immunotherapy
Fas
PVR
Online Access:https://www.mdpi.com/2072-6694/13/17/4368

Internet

https://www.mdpi.com/2072-6694/13/17/4368

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