Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism

Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism

We show that TANGO2 in mammalian cells localizes predominantly to mitochondria and partially at mitochondria sites juxtaposed to lipid droplets (LDs) and the endoplasmic reticulum. HepG2 cells and fibroblasts of patients lacking TANGO2 exhibit enlarged LDs. Quantitative lipidomics revealed a marked...

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Bibliographic Details
Main Authors: Agustin Leonardo Lujan, Ombretta Foresti, Conor Sugden, Nathalie Brouwers, Alex Mateo Farre, Alessio Vignoli, Mahshid Azamian, Alicia Turner, Jose Wojnacki, Vivek Malhotra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
TANGO2
lipid droplet
reactive oxygen species
acyl-CoA
lysophosphatidic acid
lipid peroxidation
Online Access:https://elifesciences.org/articles/85345

Internet

https://elifesciences.org/articles/85345

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