Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells

Abstract Background CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigens and immunosuppressive tumor microenvironment (TME) have been suggeste...

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Bibliographic Details
Main Authors: Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh, Jamshid Hadjati
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Mesothelin
Chimeric antigen receptor
Adenosine 2a-receptor
Genetic targeting
Pharmacological targeting
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13046-020-01546-6

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http://link.springer.com/article/10.1186/s13046-020-01546-6

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