Soluble Epoxide Hydrolase Inhibition by <i>t</i>-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Soluble Epoxide Hydrolase Inhibition by <i>t</i>-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Brown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and s...

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Bibliographic Details
Main Authors: Haley Overby, Yang Yang, Xinyun Xu, Katherine Graham, Kelsey Hildreth, Sue Choi, Debin Wan, Christophe Morisseau, Darryl C. Zeldin, Bruce D. Hammock, Shu Wang, Ahmed Bettaieb, Ling Zhao
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
soluble epoxide hydrolase
soluble epoxide hydrolase inhibitor
<i>t</i>-TUCB
brown adipose tissue
brown adipogenesis
Online Access:https://www.mdpi.com/1422-0067/21/19/7039

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https://www.mdpi.com/1422-0067/21/19/7039

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