PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair

PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair

Abstract DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA methyltransferase (MGMT) in a single-step catalysis of alkyl-group removal. O6meG...

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Bibliographic Details
Main Authors: Jodie D. Cropper, Dauren S. Alimbetov, Kevin T. G. Brown, Rostislav I. Likhotvorik, Andrew J. Robles, James T. Guerra, Boxue He, Yidong Chen, Youngho Kwon, Raushan T. Kurmasheva
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Hematology & Oncology
Subjects:
DNA damage and repair
Protein interaction
PARP1
MGMT
O6-Methylguanine
Cancer therapy
Online Access:https://doi.org/10.1186/s13045-022-01367-4

Internet

https://doi.org/10.1186/s13045-022-01367-4

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