KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas

Abstract A growing body of evidence suggests that the histone demethylase-lysine demethylase 5 (KDM5) family is associated with drug resistance in cancer cells. However, it is still not clear whether KDM5 family members promote chemotherapy resistance in pancreatic ductal adenocarcinomas (PDAC). Com...

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Bibliographic Details
Main Authors: Dan Wang, Yingjun Zhang, Zhouning Liao, Heming Ge, Cenap Güngör, Yuqiang Li
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44536-2