Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma

Prognostic and Therapeutic Roles of the Insulin Growth Factor System in Glioblastoma

Glioblastoma multiforme (GBM) is the most common primary brain malignancy and is often resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the overall survival of GBM patients remains extremely poor. Insulin-like growth factor (IGF) signaling entails a complex sys...

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Bibliographic Details
Main Authors: Elena Tirrò, Michele Massimino, Chiara Romano, Federica Martorana, Maria Stella Pennisi, Stefania Stella, Giuliana Pavone, Sandra Di Gregorio, Adriana Puma, Cristina Tomarchio, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
insulin/insulin-like growth factor system
insulin-like growth factor signaling pathway
IGF-binding protein
glioblastoma
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.612385/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.612385/full

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