Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth

Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth

Summary: Tumor-draining lymph node dendritic cells (DCs) are poor stimulators of tumor antigen-specific CD4 T cells; however, the mechanism behind this defect is unclear. We now show that, in tumor-draining lymph node DCs, a large proportion of major histocompatibility complex class II (MHC-II) mole...

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Detaylı Bibliyografya
Asıl Yazarlar: Joanna Bandola-Simon, Yoshinaga Ito, Kai W. Wucherpfennig, Paul A. Roche
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2025-01-01
Seri Bilgileri:Cell Reports
Konular:
CP: Immunology
CP: Cancer
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2211124724015018

Internet

http://www.sciencedirect.com/science/article/pii/S2211124724015018

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