Utilization of alginate with gum acacia/pectin/carrageenan as precipitation inhibitor to improve bioavailability in drug supersaturation: A case study of ketoconazole
Weak base drugs tend to precipitate in the intestine, leading to a decrease in their bioavailability. Precipitation initiates with supersaturation due to a pH shift from the stomach to the small intestine. Using natural polymers as precipitation inhibitors is still limited and has not yielded optima...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266689392300110X |