Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation

Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation

The development of new strategies based on the use of Tr1 cells has taken relevance to induce long-term tolerance, especially in the context of allogeneic stem cell transplantation. Although Tr1 cells are currently identified by the co-expression of CD49b and LAG-3 and high production of interleukin...

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Bibliographic Details
Main Authors: Saúl Arteaga-Cruz, Arimelek Cortés-Hernández, Evelyn Katy Alvarez-Salazar, Katya Rosas-Cortina, Christian Aguilera-Sandoval, Luis E. Morales-Buenrostro, Josefina M. Alberú-Gómez, Gloria Soldevila
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
Type 1 Tregs
allospecific
expansion
transplantation
tolerance
inflammatory cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1062456/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1062456/full

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