Enhanced Autophagic Flux, Suppressed Apoptosis and Reduced Macrophage Infiltration by Dasatinib in Kidneys of Obese Mice

Enhanced Autophagic Flux, Suppressed Apoptosis and Reduced Macrophage Infiltration by Dasatinib in Kidneys of Obese Mice

Obesity causes renal changes (ORC), characterized by defective renal autophagy, lipogenesis, enhanced macrophage infiltration and apoptosis. We hypothesize that Dasatinib, a tyrosine kinase inhibitor, may ameliorate changes associated with obesity. We the mice with either Obesogenic diet (OD) or a s...

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Bibliographic Details
Main Authors: Hassan Reda Hassan Elsayed, Randa El-Gamal, Mohammed R. Rabei, Mona G. Elhadidy, Shereen Hamed, Basma H. Othman, Mohamed Mahmoud Abdelraheem Elshaer, Mostafa Khaled Sedky, Ahmed Tarek Abd Elbaset Hassan, Mohammad El-Nablaway
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
macrophages
obesity
Dasatinib
tyrosine kinase inhibitors
autophagy
Online Access:https://www.mdpi.com/2073-4409/11/4/746

Internet

https://www.mdpi.com/2073-4409/11/4/746

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