Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice

Abstract Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We investigated the capacity of a highly selective A3 adeno...

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Bibliographic Details
Main Authors: Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Acta Neuropathologica Communications
Subjects:
Chemotherapy
Cisplatin
Adenosine
A3AR
Cognitive impairment
Sensorimotor deficit
Online Access:https://doi.org/10.1186/s40478-022-01315-w

Internet

https://doi.org/10.1186/s40478-022-01315-w

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