Platelet Cyclic GMP Levels Are Reduced in Patients with Primary Aldosteronism

Platelet Cyclic GMP Levels Are Reduced in Patients with Primary Aldosteronism

Background and aim: Nitric oxide inhibits platelet aggregation by increasing the second messenger cyclic guanosine-3′,5′-monophosphate (cGMP) through the activation of soluble guanylyl cyclase in target cells. Within this context, the oxidative stress associated with the aldosterone excess impairs t...

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Bibliographic Details
Main Authors: Carla Sala, Marta Rescaldani, Elisa Gherbesi, Gianni Bolla, Cesare Cuspidi, Massimiliano Ruscica, Stefano Carugo
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Journal of Clinical Medicine
Subjects:
cyclic guanosine-3′,5′-monophosphate
essential hypertension
nitric oxide
primary aldosteronism
Online Access:https://www.mdpi.com/2077-0383/12/22/7081

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https://www.mdpi.com/2077-0383/12/22/7081

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