Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing

Astragalus polysaccharide improves diabetic ulcers by promoting M2-polarization of macrophages to reduce excessive inflammation via the β-catenin/ NF-κB axis at the late phase of wound-healing

Ethnopharmacological relevance: Astragalus polysaccharide (APS), the most biologically active ingredient of Astragali Radix, is used to treat diabetes mellitus (DM)-related chronic wounds in traditional Chinese medicine for several decades. This herb possesses an anti-inflammatory effect. Our study...

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Bibliographic Details
Main Authors: Zhang Zhen, Shan Wei, Wang Yunfei, Xing Jie, Xu Jienan, Shen Yiting, Xiao Wen, Guo Shuyu, Liang Yue, Wang Xuanyu, Zhong Yumei, Que Huafa
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Heliyon
Subjects:
Astragalus polysaccharide
Wound-healing
Macrophages
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024006753

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http://www.sciencedirect.com/science/article/pii/S2405844024006753

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