Macrophage depletion by liposome-encapsulated clodronate suppresses seizures but not hippocampal damage after acute viral encephalitis

Viral encephalitis is a major risk factor for the development of seizures and epilepsy, but the underlying mechanisms are only poorly understood. Mouse models such as viral encephalitis induced by intracerebral infection with Theiler's virus in C57BL/6 (B6) mice allow advancing our understandin...

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Bibliographic Details
Main Authors: Inken Waltl, Christopher Käufer, Sonja Bröer, Chintan Chhatbar, Luca Ghita, Ingo Gerhauser, Muneeb Anjum, Ulrich Kalinke, Wolfgang Löscher
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302796