Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia.

The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene co-expression network algorithms (e.g., WGCNA). To improve reliability with this method it is critical to remove unwanted sources of varianc...

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Bibliographic Details
Main Authors: Eugenia Radulescu, Qiang Chen, Giulio Pergola, Pasquale Di Carlo, Shizhong Han, Joo Heon Shin, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-10-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010989&type=printable