Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte

Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte

BackgroundDiabetic cardiomyopathy (DbCM) is characterized by initial impairment of left ventricular relaxation followed by contractile dysfunction. Despite intensive research, the exact mechanism remains so far unsolved.MethodsWe constructed weighted gene co-expression network analysis (WGCNA) to sc...

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Bibliographic Details
Main Authors: Lei Dai, Yang Xie, Wenjun Zhang, Xiaodan Zhong, Mengwen Wang, Hongcheng Jiang, Zhen He, Xiaolei Liu, Hesong Zeng, Hongjie Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
diabetic cardiomyopathy
weighted gene co-expression network analysis (WGCNA)
ANGPTL4
focal adhesion kinase
NADPH oxidase
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.705154/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.705154/full

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