Crosstalk between Cancer Cells and Cancer-Associated Fibroblasts Mediated by TGF-β1–IGFBP7 Signaling Promotes the Progression of Infiltrative Gastric Cancer

Crosstalk between Cancer Cells and Cancer-Associated Fibroblasts Mediated by TGF-β1–IGFBP7 Signaling Promotes the Progression of Infiltrative Gastric Cancer

Patients with infiltrative-type gastric cancer (GC) (Ming’s classification) have a poor prognosis due to more metastasis and recurrence. Cancer-associated fibroblasts (CAFs) in infiltrative-type extracellular matrix (ECM) have specific characteristics compared with those of expansive types with resp...

Full description

Bibliographic Details
Main Authors:	Zhijun Hong, Wen Xie, Huiqin Zhuo, Xujin Wei, Kang Wang, Jia Cheng, Lingyun Lin, Jingjing Hou, Xin Chen, Jianchun Cai
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Series:	Cancers
Subjects:	gastric cancer metastasis Ming classification cancer-associated fibroblast IGFBP7 TGF-β1
Online Access:	https://www.mdpi.com/2072-6694/15/15/3965

Similar Items

TGF‐β‐induced IGFBP‐3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion
by: Rocío Navarro, et al.
Published: (2020-10-01)

Heterogeneity in Pancreatic Cancer Fibroblasts—TGFβ as a Master Regulator?
by: Dale M. Watt, et al.
Published: (2021-10-01)

Multi-Transcriptomic Analysis Reveals the Heterogeneity and Tumor-Promoting Role of SPP1/CD44-Mediated Intratumoral Crosstalk in Gastric Cancer
by: Wen Xie, et al.
Published: (2022-12-01)

Cancer-associated fibroblast infiltration in gastric cancer: the discrepancy in subtypes pathways and immunosuppression
by: Xu Liu, et al.
Published: (2021-07-01)

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study
by: Ann H. Rosendahl, et al.
Published: (2021-03-01)

The Crosstalk between GPR81/IGFBP6 Promotes Breast Cancer Progression by Modulating Lactate Metabolism and Oxidative Stress
by: Lucia Longhitano, et al.
Published: (2022-01-01)

Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapy
by: Angélique Vienot, et al.
Published: (2022-12-01)

Radiation‐induced effects on TGF‐β and PDGF receptor signaling in cancer‐associated fibroblasts
by: Nannan Yang, et al.
Published: (2024-03-01)

Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer
by: Yuichiro Miki, et al.
Published: (2020-10-01)

IGFBP-4: A promising biomarker for lung cancer
by: Nur Savas Irem, et al.
Published: (2021-01-01)

Gold Nanoparticles Disrupt the IGFBP2/mTOR/PTEN Axis to Inhibit Ovarian Cancer Growth
by: Md. Nazir Hossen, et al.
Published: (2022-11-01)

Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal Cancer
by: Naoya Miyashita, et al.
Published: (2021-10-01)

Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating selected features of TGFβ inhibition
by: Tiffany Luong, et al.
Published: (2022-12-01)

Expression characteristics and their functional role of IGFBP gene family in pan-cancer
by: Yingnan Liu, et al.
Published: (2023-04-01)

IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer
by: Qing Cai, et al.
Published: (2020-05-01)

ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis
by: Sergey Nikulin, et al.
Published: (2023-01-01)

Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression
by: Masaki Shimizu, et al.
Published: (2021-09-01)

TGFβ1 in Cancer-Associated Fibroblasts Is Associated With Progression and Radiosensitivity in Small-Cell Lung Cancer
by: Jiaqi Zhang, et al.
Published: (2021-05-01)

Intrinsic, pro-apoptotic effects of IGFBP-3 on breast cancer cells are reversible: Involvement of PKA, Rho and ceramide.
by: Claire M Perks, et al.
Published: (2011-05-01)

Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer
by: Amir Ansari, et al.
Published: (2024-01-01)

Interaction between GRP78 and IGFBP-3 Affects Tumourigenesis and Prognosis in Breast Cancer Patients
by: Hanna A. Zielinska, et al.
Published: (2020-12-01)

A Genomic Signature Reflecting Fibroblast Infiltration Into Gastric Cancer Is Associated With Prognosis and Treatment Outcomes of Immune Checkpoint Inhibitors
by: Yi Lu, et al.
Published: (2022-04-01)

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts
by: Xueke Shi, et al.
Published: (2020-12-01)

Long-Term <i>Helicobacter pylori</i> Infection Switches Gastric Epithelium Reprogramming towards Cancer Stem Cell-Related Differentiation Program in <i>Hp</i>-Activated Gastric Fibroblast-TGFβ Dependent Manner
by: Gracjana Krzysiek-Maczka, et al.
Published: (2020-10-01)

IGFBP-1 Expression Promotes Tamoxifen Resistance in Breast Cancer Cells via Erk Pathway Activation
by: Yan Zheng, et al.
Published: (2020-05-01)

Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis
by: Qing Cai, et al.
Published: (2022-11-01)

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
by: Huocong Huang, et al.
Published: (2019-11-01)

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis
by: Arcangelo Liso, et al.
Published: (2022-04-01)

Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities
by: Jordi Alcaraz, et al.
Published: (2021-07-01)

The cellular triumvirate: fibroblasts entangled in the crosstalk between cancer cells and immune cells
by: Adel Fergatova, et al.
Published: (2024-01-01)

Fibroblast-Derived Extracellular Vesicles Induce Colorectal Cancer Progression by Transmitting Amphiregulin
by: Ádám Oszvald, et al.
Published: (2020-07-01)

PPARγ induces growth inhibition and apoptosis through upregulation of insulin-like growth factor-binding protein-3 in gastric cancer cells
by: S.Y. Kim, et al.
Published: (2015-03-01)

PPARγ induces growth inhibition and apoptosis through upregulation of insulin-like growth factor-binding protein-3 in gastric cancer cells
by: S.Y. Kim, et al.
Published: (2015-01-01)

Editorial: The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease
by: Shin-Ichiro Takahashi, et al.
Published: (2022-04-01)

Prognostic Value of Circulating Cytokines in Chemorefractory Colorectal Cancer
by: Irene Assaf, et al.
Published: (2023-12-01)

Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer
by: Ece Ozmen, et al.
Published: (2024-03-01)

Impact of TGF-β1 expression and -509C>T polymorphism in the TGF-β1 gene on the progression and survival of gastric cancer
by: Julian Ananiev, et al.
Published: (2017-11-01)

IGFBP-1 forms associated with placental cell membranes
by: Masnikosa Romana, et al.
Published: (2009-01-01)

IGFBP-1 forms associated with placental cell membranes
by: ROMANA MASNIKOSA, et al.
Published: (2009-07-01)

Adipocytes contribute to tumor progression and invasion of peritoneal metastasis by interacting with gastric cancer cells as cancer associated fibroblasts
by: Toshihide Hamabe‐Horiike, et al.
Published: (2023-01-01)