HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing

HDAC6-selective inhibitor CAY10603 ameliorates cigarette smoke-induced small airway remodeling by regulating epithelial barrier dysfunction and reversing

Abstract Background Small airway remodelling is a vital characteristic of chronic obstructive pulmonary disease (COPD), which is mainly caused by epithelial barrier dysfunction and epithelial-mesenchymal transition (EMT). Recent studies have indicated that histone deacetylase 6 (HDAC6) plays an impo...

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Bibliographic Details
Main Authors: Qin Zhang, Liming Yan, Ye Lu, Xiaodong Liu, Yan Yin, Qiuyue Wang, Xiu Gu, Xiaoming Zhou
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Respiratory Research
Subjects:
HDAC6
COPD
Cigarette smoke
Airway remodelling
CAY10603
Online Access:https://doi.org/10.1186/s12931-024-02688-3

Internet

https://doi.org/10.1186/s12931-024-02688-3

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