Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression.

Mutant MMP-9 and HGF gene transfer enhance resolution of CCl4-induced liver fibrosis in rats: role of ASH1 and EZH2 methyltransferases repression.

Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2...

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Bibliographic Details
Main Authors: Hussein Atta, Mahmoud El-Rehany, Olfat Hammam, Hend Abdel-Ghany, Maggie Ramzy, Martin Roderfeld, Elke Roeb, Ayman Al-Hendy, Salama Abdel Raheim, Hatem Allam, Heba Marey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4224431?pdf=render

Internet

http://europepmc.org/articles/PMC4224431?pdf=render

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