Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1

KCa2.1, KCa2.2, KCa2.3 and KCa3.1 constitute a family of mammalian small- to intermediate-conductance potassium channels that are activated by calcium-calmodulin. KCa3.1 is unique among these four channels in that activation requires, in addition to calcium, phosphorylation of a single histidine res...

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Bibliographic Details
Main Authors: Shekhar Srivastava, Saswati Panda, Zhai Li, Stephen R Fuhs, Tony Hunter, Dennis J Thiele, Stevan R Hubbard, Edward Y Skolnik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
potassium channel
histidine phosphorylation
copper inhibition
Online Access:https://elifesciences.org/articles/16093

Internet

https://elifesciences.org/articles/16093

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