S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] in the antidepressant-like response of ketamine, and modulation of 5-HT1B recept...

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Bibliographic Details
Main Authors: Kristian G. du Jardin, Nico Liebenberg, Manuel Cajina, Heidi K. Müller, Betina Elfving, Connie Sanchez, Gregers Wegener
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
serotonin (5-hydroxytryptamine
5-HT)
ketamine
antidepressants
forced swim test
CP94253
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00978/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00978/full

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