A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.

A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.

GspB is a serine-rich repeat (SRR) adhesin of Streptococcus gordonii that mediates binding of this organism to human platelets via its interaction with sialyl-T antigen on the receptor GPIbα. This interaction appears to be a major virulence determinant in the pathogenesis of infective endocarditis....

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Bibliographic Details
Main Authors: Tasia M Pyburn, Barbara A Bensing, Yan Q Xiong, Bruce J Melancon, Thomas M Tomasiak, Nicholas J Ward, Victoria Yankovskaya, Kevin M Oliver, Gary Cecchini, Gary A Sulikowski, Matthew J Tyska, Paul M Sullam, T M Iverson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3131266?pdf=render

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http://europepmc.org/articles/PMC3131266?pdf=render

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