Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem. Most of the diversity is generated by two mechanisms: V(D)J gene recombination and somatic hypermutation (SHM). SHM intr...

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Bibliographic Details
Main Authors: Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez Carreon, Elba A. Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz Zamora
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
light chain (AL) amyloidosis
somatic hypermutation
V(D)J rearrangement
protein aggregation
amyloid
immune system
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203425/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203425/full

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