Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem. Most of the diversity is generated by two mechanisms: V(D)J gene recombination and somatic hypermutation (SHM). SHM intr...

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Bibliographic Details
Main Authors:	Luis Del Pozo-Yauner, Guillermo A. Herrera, Julio I. Perez Carreon, Elba A. Turbat-Herrera, Francisco J. Rodriguez-Alvarez, Robin A. Ruiz Zamora
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Series:	Frontiers in Immunology
Subjects:	light chain (AL) amyloidosis somatic hypermutation V(D)J rearrangement protein aggregation amyloid immune system
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203425/full

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