Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.

Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown. In this study, we addressed this issue in human cancer cells in respo...

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Bibliographic Details
Main Authors: Qing-Bing Zha, Xiao-Yu Zhang, Qiu-Ru Lin, Li-Hui Xu, Gao-Xiang Zhao, Hao Pan, Dan Zhou, Dong-Yun Ouyang, Ze-Huan Liu, Xian-Hui He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4430304?pdf=render

Internet

http://europepmc.org/articles/PMC4430304?pdf=render

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