Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment

Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment

BackgroundNutritional epidemiology has shown that inadequate dietary protein intake is associated with poor brain function in the elderly population. The plasma free amino acid (PFAA) profile reflects nutritional status and may have the potential to predict future changes in cognitive function. Here...

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Main Authors: Takeshi Ikeuchi, Mayuka Kanda, Hitomi Kitamura, Fumiyoshi Morikawa, Shuta Toru, Chika Nishimura, Kensaku Kasuga, Takayoshi Tokutake, Tetsuya Takahashi, Yasuko Kuroha, Nobuhiko Miyazawa, Shin Tanaka, Kumiko Utsumi, Kenjiro Ono, Satoshi Yano, Tadanori Hamano, Satoshi Naruse, Ryuji Yajima, Noriko Kawashima, Chikako Kaneko, Hisatsugu Tachibana, Yuki Yano, Yumiko Kato, Sakino Toue, Hiroko Jinzu, Akihiko Kitamura, Yuri Yokoyama, Eiji Kaneko, Minoru Yamakado, Kenji Nagao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Nutrition
Subjects:
multicenter clinical study
protein malnutrition
biomarker discovery
MMSE–Mini-Mental State Examination
APOE
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.1040476/full

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https://www.frontiersin.org/articles/10.3389/fnut.2022.1040476/full

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