Improvement of non-invasive tests of liver steatosis and fibrosis as indicators for non-alcoholic fatty liver disease in type 2 diabetes mellitus patients with elevated cardiovascular risk profile using the PPAR-α/γ agonist aleglitazar.

Improvement of non-invasive tests of liver steatosis and fibrosis as indicators for non-alcoholic fatty liver disease in type 2 diabetes mellitus patients with elevated cardiovascular risk profile using the PPAR-α/γ agonist aleglitazar.

<h4>Background</h4>Peroxisome proliferator-activated receptor (PPAR) agonists may have favorable outcomes on non-alcoholic fatty liver disease. This study serves as proof of concept to evaluate whether dual PPAR-α/γ agonists improve non-invasive tests of liver steatosis and fibrosis.<...

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Main Authors: Esmée J Grobbee, Vivian D de Jong, Ilse C Schrieks, Maarten E Tushuizen, Adriaan G Holleboom, Jean-Claude Tardif, A Michael Lincoff, Gregory G Schwartz, Manuel Castro Cabezas, Diederick E Grobbee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0277706

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https://doi.org/10.1371/journal.pone.0277706

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