Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases

Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the central nervous system (CNS). Sialic acid-binding immunoglobulin-like lectins (SIGLECs) expressed on microglia are ke...

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Bibliographic Details
Main Authors: Jannis Wißfeld, Tawfik Abou Assale, German Cuevas-Rios, Huan Liao, Harald Neumann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Neurology
Subjects:
SIGLEC
sialylation
sialic acid
microglia
neuroinflammation
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1330874/full

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https://www.frontiersin.org/articles/10.3389/fneur.2024.1330874/full

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