TGF-β<sub>1</sub> Potentiates the Cytotoxicity of Cadmium by Induction of a Metal Transporter, ZIP8, Mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK Signal Pathways in Cultured Vascular Endothelial Cells

TGF-β<sub>1</sub> Potentiates the Cytotoxicity of Cadmium by Induction of a Metal Transporter, ZIP8, Mediated by the ALK5-Smad2/3 and ALK5-Smad3-p38 MAPK Signal Pathways in Cultured Vascular Endothelial Cells

Vascular endothelial cells cover the luminal surface of blood vessels in a monolayer and play a role in the regulation of vascular functions, such as the blood coagulation-fibrinolytic system. When the monolayer is severely or repeatedly injured, platelets aggregate at the damaged site and release t...

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Bibliographic Details
Main Authors: Keisuke Ito, Tomoya Fujie, Masahiro Shimomura, Tsuyoshi Nakano, Chika Yamamoto, Toshiyuki Kaji
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cadmium
endothelial cell
Zrt- and Irt-like protein transporter
transforming growth factor-β<sub>1</sub>
Smad2/3
p38 MAPK
Online Access:https://www.mdpi.com/1422-0067/23/1/448

Internet

https://www.mdpi.com/1422-0067/23/1/448

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