Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs

Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs

The cerebral synthesis of cholesterol is mainly handled by astrocytes, which are also responsible for apoproteins’ synthesis and lipoproteins’ assembly required for the cholesterol transport in the brain parenchyma. In Alzheimer disease (AD), these processes are impaired, likely because of the astro...

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Bibliographic Details
Main Authors: Giulia Sierri, Roberta Dal Magro, Barbara Vergani, Biagio Eugenio Leone, Beatrice Formicola, Lorenzo Taiarol, Stefano Fagioli, Marcelo Kravicz, Lucio Tremolizzo, Laura Calabresi, Francesca Re
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
brain cholesterol
Alzheimer disease
HDL
ABCA1
astrocytes
nanoparticles
Online Access:https://www.mdpi.com/1422-0067/23/1/102

Internet

https://www.mdpi.com/1422-0067/23/1/102

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