LDH and PDH Activities in the Ischemic Brain and the Effect of Reperfusion—An Ex Vivo MR Study in Rat Brain Slices Using Hyperpolarized [1-<sup>13</sup>C]Pyruvate

LDH and PDH Activities in the Ischemic Brain and the Effect of Reperfusion—An Ex Vivo MR Study in Rat Brain Slices Using Hyperpolarized [1-<sup>13</sup>C]Pyruvate

Ischemic stroke is a leading cause for neurologic disability worldwide, for which reperfusion is the only available treatment. Neuroimaging in stroke guides treatment, and therefore determines the clinical outcome. However, there are currently no imaging biomarkers for the status of the ischemic bra...

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Bibliographic Details
Main Authors: Gal Sapir, David Shaul, Naama Lev-Cohain, Jacob Sosna, Moshe J. Gomori, Rachel Katz-Brull
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Metabolites
Subjects:
ischemic stroke
reperfusion
lactate dehydrogenase
pyruvate dehydrogenase
dissolution dynamic nuclear polarization
brain slices
Online Access:https://www.mdpi.com/2218-1989/11/4/210

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https://www.mdpi.com/2218-1989/11/4/210

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