Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing

Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing

Abstract Long interspersed nuclear elements-1 (L1s) are a large family of retrotransposons. Retrotransposons are repetitive sequences that are capable of autonomous mobility via a copy-and-paste mechanism. In most copy events, only the L1 sequence is inserted, however, they can also mobilize the fla...

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Bibliographic Details
Main Authors: Barun Pradhan, Tatiana Cajuso, Riku Katainen, Päivi Sulo, Tomas Tanskanen, Outi Kilpivaara, Esa Pitkänen, Lauri A. Aaltonen, Liisa Kauppi, Kimmo Palin
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Scientific Reports
Subjects:
Nanopore Sequencing
Oxford Nanopore Technologies
Long Interspersed Nuclear Elements (LINE)
Candidate Insertion
Target-primed Reverse Transcription (TPRT)
Online Access:https://doi.org/10.1038/s41598-017-15076-3

Internet

https://doi.org/10.1038/s41598-017-15076-3

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