Initial treatment with a single capsule containing half-dose quadruple therapy versus standard-dose dual therapy in hypertensive patients (QUADUAL): statistical analysis plan for a randomized, blinded, crossover trial

Initial treatment with a single capsule containing half-dose quadruple therapy versus standard-dose dual therapy in hypertensive patients (QUADUAL): statistical analysis plan for a randomized, blinded, crossover trial

Abstract Background Combined antihypertensive therapy has obvious advantages over single drug therapy. Hypertension guidelines fully affirm the efficacy of dual combination in initial antihypertensive therapy. Recent studies have also pointed out that the quadruple combination of very low-dose antih...

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Bibliographic Details
Main Authors: Xiexiong Zhao, Xingli Li, Tao Liu, Guoping Yang, Ye Chen, Miao Huang, Lin Zhao, Xiaogang Li, Weihong Jiang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Trials
Subjects:
Hypertension
Statistical analysis plan
Antihypertensive
Low-dose combination
Randomized controlled trial
Online Access:https://doi.org/10.1186/s13063-023-07803-1

Internet

https://doi.org/10.1186/s13063-023-07803-1

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