Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia

Hyperactive Natural Killer cells in Rag2 knockout mice inhibit the development of acute myeloid leukemia

Abstract Immunotherapy has attracted considerable attention as a therapeutic strategy for cancers including acute myeloid leukemia (AML). In this study, we found that the development of several aggressive subtypes of AML is slower in Rag2 −/− mice despite the lack of B and T lymphocytes, even compar...

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Bibliographic Details
Main Authors: Emi Sugimoto, Jingmei Li, Yasutaka Hayashi, Kohei Iida, Shuhei Asada, Tsuyoshi Fukushima, Moe Tamura, Shiori Shikata, Wenyu Zhang, Keita Yamamoto, Kimihito Cojin Kawabata, Tatsuya Kawase, Takeshi Saito, Taku Yoshida, Satoshi Yamazaki, Yuta Kaito, Yoichi Imai, Tamami Denda, Yasunori Ota, Tomofusa Fukuyama, Yosuke Tanaka, Yutaka Enomoto, Toshio Kitamura, Susumu Goyama
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05606-3

Internet

https://doi.org/10.1038/s42003-023-05606-3

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