Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABA<sub>A</sub> Receptor Point Mutations

Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABA<sub>A</sub> Receptor Point Mutations

Point mutations in the β2 (N265S) and β3 (N265M) subunits of γ-amino butyric acid type A receptors (GABA<sub>A</sub>Rs) that render them insensitive to the general anesthetics etomidate and propofol have been used to link modulation of β2-GABA<sub>A</sub>Rs to sedation and β3...

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Bibliographic Details
Main Authors: Alifayaz Abdulzahir, Steven Klein, Chong Lor, Mark G. Perkins, Alyssa Frelka, Robert A. Pearce
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
anesthetic action
general anesthesia
amnesia
GABA
intravenous anesthetics
contextual memory
Online Access:https://www.mdpi.com/1422-0067/24/6/5637

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https://www.mdpi.com/1422-0067/24/6/5637

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