Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity

Chagas disease causes ~10,000 deaths each year, mainly in Latin America, where it is endemic. The currently available chemotherapeutic agents are ineffective in the chronic stage of the disease, and the lack of pharmaceutical innovation for Chagas disease highlights the urgent need for the developme...

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Bibliographic Details
Main Authors: Rafael A. A. Ferreira, Ivani Pauli, Thiago S. Sampaio, Mariana L. de Souza, Leonardo L. G. Ferreira, Luma G. Magalhães, Celso de O. Rezende, Rafaela S. Ferreira, Renata Krogh, Luiz C. Dias, Adriano D. Andricopulo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
Chagas disease
Trypanosoma cruzi
cruzain
SAR
medicinal chemistry
synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00798/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00798/full

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