Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators

Ajwa dates (Phoenix dactylifera L.) attenuate cisplatin-induced nephrotoxicity in rats via augmenting Nrf2, modulating NADPH oxidase-4 and mitigating inflammatory/apoptotic mediators

In the therapy of cisplatin (CP), nephrotoxicity is a main limiting issue that associated with oxidative stress and apoptosis. According to many studies, the antioxidant and anti-inflammatory properties of Ajwa dates are very strong, due to the unique phytochemical profile. Here, we investigated the...

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Bibliographic Details
Main Authors: Eman A. Abdelghffar, Wael A. Obaid, Zuhair M. Mohammedsaleh, Wafae Ouchari, Omayma A. Eldahshan, Mansour Sobeh
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Phoenix dactylifera
Ajwa dates
LC-MS/MS
Antioxidant
Anti-inflammatory Nephroprotective
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012252

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http://www.sciencedirect.com/science/article/pii/S0753332222012252

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