ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

Summary: Retinal pigment epithelium (RPE) dysfunction and choroidal neovascularization (CNV) are predominant features of age-related macular degeneration (AMD), with an unclear mechanism. Herein, we show that RNA demethylase α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) is up-regulat...

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Bibliographic Details
Main Authors: Ru-Xu Sun, Hong-Jing Zhu, Ye-Ran Zhang, Jia-Nan Wang, Ying Wang, Qiu-Chen Cao, Jiang-Dong Ji, Chao Jiang, Song-Tao Yuan, Xue Chen, Qing-Huai Liu
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007908

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http://www.sciencedirect.com/science/article/pii/S2211124723007908

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