The Distribution of Charged Amino Acid Residues and the Ca2+ Permeability of Nicotinic Acetylcholine Receptors: A Predictive Model

The Distribution of Charged Amino Acid Residues and the Ca2+ Permeability of Nicotinic Acetylcholine Receptors: A Predictive Model

Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca2+ permeability depending on their subunit composition. The Ca2+ permeability is a crucial functional parameter to understand the physiological role of nAChRs, in particular considering th...

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Bibliographic Details
Main Author: Sergio Fucile
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
fractional Ca2+ current
ion selectivity
nicotinic subunits
charged amino acids
nicotine dependence
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00155/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00155/full

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