Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model

Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model

Capsid assembly modulators (CAMs) have emerged as a promising class of antiviral agents. We studied the effects of twenty-one newly designed and synthesized CAMs including heteroaryldihydropyrimidine compounds (HAPs), their analogs and standard compounds on hepatitis B virus (HBV) capsid assembly. C...

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Bibliographic Details
Main Authors: Karina Spunde, Brigita Vigante, Unda Nelda Dubova, Anda Sipola, Irena Timofejeva, Anna Zajakina, Juris Jansons, Aiva Plotniece, Karlis Pajuste, Arkadij Sobolev, Ruslan Muhamadejev, Kristaps Jaudzems, Gunars Duburs, Tatjana Kozlovska
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
hepatitis B virus
antivirals
full-length HBV core
capsid assembly
capsid assembly modulator
heteroaryldihydropyrimidines
Online Access:https://www.mdpi.com/1424-8247/15/7/773

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https://www.mdpi.com/1424-8247/15/7/773

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