Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium

ABSTRACT Human macrophages and the eukaryotic microbe Dictyostelium discoideum ingest bacteria by phagocytosis, and then kill the ingested bacteria. Some pathogenic bacteria secrete linear chains of phosphate residues (polyphosphate; polyP), and the polyP prevents some of the phagocytes from killing...

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Bibliographic Details
Main Authors: Ryan J. Rahman, Ramesh Rijal, Shiyu Jing, Te-An Chen, Issam Ismail, Richard H. Gomer
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
polyphosphate
Dictyostelium
phagocytosis
bacterial survival
Online Access:https://journals.asm.org/doi/10.1128/mbio.01939-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01939-23

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