Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae

Developmental Toxicity and Biotransformation of Two Anti-Epileptics in Zebrafish Embryos and Early Larvae

The zebrafish (<i>Danio rerio</i>) embryo is gaining interest as a bridging tool between in-vitro and in-vivo developmental toxicity studies. However, cytochrome P450 (CYP)-mediated drug metabolism in this model is still under debate. Therefore, we investigated the potential of zebrafish...

Full description

Bibliographic Details
Main Authors: Chloé Bars, Jente Hoyberghs, Allan Valenzuela, Laura Buyssens, Miriam Ayuso, Chris Van Ginneken, Alain J. Labro, Kenn Foubert, Steven J. Van Cruchten
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
developmental toxicology
in vitro
zebrafish
embryo
drug metabolism
bioactivation
Online Access:https://www.mdpi.com/1422-0067/22/23/12696

Internet

https://www.mdpi.com/1422-0067/22/23/12696

Similar Items