The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

Young female cancer patients can develop chemotherapy-induced primary ovarian insufficiency (POI). Cyclophosphamide (Cy) is one of the most widely used chemotherapies and has the highest risk of damaging the ovaries. Recent studies elucidated the pivotal roles of cellular senescence, which is charac...

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Bibliographic Details
Main Authors: Zixin Xu, Nozomi Takahashi, Miyuki Harada, Chisato Kunitomi, Akari Kusamoto, Hiroshi Koike, Tsurugi Tanaka, Nanoka Sakaguchi, Yoko Urata, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
cellular senescence
cyclophosphamide
primary ovarian insufficiency
senolytics
senotherapeutics
Online Access:https://www.mdpi.com/1422-0067/24/24/17193

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https://www.mdpi.com/1422-0067/24/24/17193

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