Whole blood transcriptional profiling reveals deregulation of oxidative and antioxidative defence genes in myelofibrosis and related neoplasms. Potential implications of downregulation of Nrf2 for genomic instability and disease progression.

Whole blood transcriptional profiling reveals deregulation of oxidative and antioxidative defence genes in myelofibrosis and related neoplasms. Potential implications of downregulation of Nrf2 for genomic instability and disease progression.

The Philadelphia-negative chronic myeloproliferative neoplasms - essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) (MPNs) - have recently been shown to be associated with chronic inflammation, oxidative stress and accumulation of reactive oxygen species (ROS). Using whol...

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Bibliographic Details
Main Authors: Hans Carl Hasselbalch, Mads Thomassen, Caroline Hasselbalch Riley, Lasse Kjær, Thomas Stauffer Larsen, Morten K Jensen, Ole Weis Bjerrum, Torben A Kruse, Vibe Skov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4232509?pdf=render

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http://europepmc.org/articles/PMC4232509?pdf=render

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