Mono-institutional phase 2 study of innovative Stereotactic Body RadioTherapy targeting PArtial Tumor HYpoxic (SBRT-PATHY) clonogenic cells in unresectable bulky non-small cell lung cancer: profound non-targeted effects by sparing peri-tumoral immune microenvironment

Mono-institutional phase 2 study of innovative Stereotactic Body RadioTherapy targeting PArtial Tumor HYpoxic (SBRT-PATHY) clonogenic cells in unresectable bulky non-small cell lung cancer: profound non-targeted effects by sparing peri-tumoral immune microenvironment

Abstract Background Radiotherapy-induced lymphopenia may be limiting the success of therapy and could also negatively affect the ability of immune system in mediating the bystander (BE) and abscopal effects (AE). A novel SBRT-based PArtial Tumor irradiation of HYpoxic clonogenic cells (SBRT-PATHY) f...

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Bibliographic Details
Main Authors: Slavisa Tubin, Mohammad K. Khan, Gerardo Salerno, Waleed F. Mourad, Weisi Yan, Branislav Jeremic
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Radiation Oncology
Subjects:
Novel unconventional SBRT
Partial irradiation
Bystander effect
Abscopal effect
Tumor hypoxia
Immune microenvironment
Online Access:http://link.springer.com/article/10.1186/s13014-019-1410-1

Internet

http://link.springer.com/article/10.1186/s13014-019-1410-1

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