Systemic Lipopolysaccharide Challenge Induces Inflammatory Changes in Rat Dorsal Root Ganglia: An Ex Vivo Study

Systemic Lipopolysaccharide Challenge Induces Inflammatory Changes in Rat Dorsal Root Ganglia: An Ex Vivo Study

Inflammatory processes within the peripheral nervous system (PNS) are associated with symptoms of hyperalgesia and allodynia. Pro-inflammatory mediators, such as cytokines or prostaglandins, modulate the excitability of nociceptive neurons, called peripheral sensitization. Here, we aimed to examine...

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Bibliographic Details
Main Authors: Franz Nürnberger, Daniela Ott, Rebecca Claßen, Christoph Rummel, Joachim Roth, Stephan Leisengang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
hyperalgesia
sickness behavior
pain
LPS
cytokines
nociceptor
Online Access:https://www.mdpi.com/1422-0067/23/21/13124

Internet

https://www.mdpi.com/1422-0067/23/21/13124

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