Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

Plasmid-launched live-attenuated vaccines (PLLAV), also called infectious DNA (iDNA) vaccines, combine the assets of genetic immunization with the potency of replication-competent live viral vaccines. However, due to their origin as bacterial plasmid DNA, efficient delivery of PLLAV may be hampered...

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Bibliographic Details
Main Authors: Sapna Sharma, Michael A. Schmid, Lorena Sanchez Felipe, Jana Grenelle, Suzanne J.F. Kaptein, Lotte Coelmont, Johan Neyts, Kai Dallmeier
Format: Article
Language:English
Published: Taylor & Francis Group 2020-09-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
plasmid-launched live-attenuated vaccine
tbk1
bx795
proviral
innate antiviral immunity
interferon signaling
self-amplifying rna vaccine
Online Access:http://dx.doi.org/10.1080/21645515.2020.1765621

Internet

http://dx.doi.org/10.1080/21645515.2020.1765621

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