Epithelial NAD+ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

Epithelial NAD+ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

IntroductionWe have previously demonstrated that a pathologic downregulation of peroxisome proliferator-activated receptor–gamma coactivator 1-alpha (PGC1α) within the intestinal epithelium contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanism underlying downreg...

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Bibliographic Details
Main Authors: Elizabeth A. Novak, Erin C. Crawford, Heather L. Mentrup, Brian D. Griffith, David M. Fletcher, Meredith R. Flanagan, Corinne Schneider, Brian Firek, Matthew B. Rogers, Michael J. Morowitz, Jon D. Piganelli, Qian Wang, Kevin P. Mollen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
colitis
PGC1α
nicotinamide riboside
poly(ADP) riboside polymers
nicotinamide adenine dinucleotide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231700/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1231700/full

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